No. All inputs on every product share a common ground internally, and that ground is also shared with the USB connection, and thus the host PC.
For more information about isolation, please see this article: What should I do to avoid accidental damage to the device?
For digital channel-to-channel isolation, we suggest considering this eval kit from SI Labs: http://www.digikey.com/product-detail/en/SI84XXISO-KIT/336-1765-ND/2170672
For isolation from the host PC, we suggest considering this USB 2.0 high-speed isolator: http://intona.eu/usbiso
Note: There are no USB 3.0 isolators on the market yet as far as we are aware.
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