No. All inputs on every product share a common ground internally, and that ground is also shared with the USB connection, and thus the host PC.
For more information about isolation, please see this article: What should I do to avoid accidental damage to the device?
For digital channel to channel isolation, we suggest considering this eval kit from SI Labs: http://www.digikey.com/product-detail/en/SI84XXISO-KIT/336-1765-ND/2170672
For isolation from the host PC, we suggest considering this USB 2.0 high speed isolator: http://intona.eu/usbiso
Note, there are no USB 3.0 isolators on the market yes as far as we are aware.
trello ID: 564d060e1d39627f2f041104